In response to the COVID-19 pandemic, Crossroads Fund housed two rapid response networks of more than 800 medical students in Chicago who identified ways to meet the gaps in prevention of the spread of COVID-19 for critical populations of people. COVID RRT established a strong model for testing for the coronavirus in overnight shelters and worked closely with public health officials to replicate the model in more shelters across Chicago. GetMePPE Chicago effectively, efficiently, and equitably distributed both local and crowdfunded donations of personal protective equipment (PPE) to hospitals and community organizations in need.